City have not reached the last four of England's most celebrated domestic tournament for 30 years and not lifted a major trophy in 35 years. Mancini's side have a chance of ending that barren run on two fronts although they have a two-goal deficit against Dynamo Kiev to overturn in the Europa League next week after losing in Ukraine on Thursday.
Mancini said: "It won't be hard to pick them up because the FA Cup is really important to us. It's a really big chance for us to get to Wembley."
He added: "When you lose a game, you want to play the day after. This won't affect us.
"The FA Cup is totally different. We know how long it's been since the last semi-final so this would be good for us, good for the club and the fans.
"It's a really difficult tie for us because Reading have shown what they are capable of by beating Everton. We know from this season's FA Cup that every tie can be hard.
"The Europa League is going to be hard for us, but we still have a chance. In football, you never know. It should be different in Manchester. The next few days will be important."
Mancini had a taste of Wembley as a player but one he does not want to repeat.
"I've only played there once," said the Italian boss. "That was in the European Cup Final in 1992 for Sampdoria against Barcelona.
"It was not a good experience. I would really like something more memorable at Wembley."
Source: PA
Source: PA