Watford are without Lewis McGugan and Iriney as they attempt to become the first English club to win away at Manchester City this season.
McGugan is ruled out with a thigh problem while Iriney has a groin strain.
They join suspended duo Fitz Hall and Alexander Merkel and the cup tied Hector Bellerin on the sidelines.
But Marco Cassetti has been passed fit after overcoming the knee problem that has kept him sidelined since the original third-round tie against Bristol City at the start of January, while loanee Mathias Ranegie could make his Hornets debut.
Manchester City top scorer Alvaro Negredo (shoulder) and playmaker David Silva (hamstring) will both miss Saturday's FA Cup fourth-round tie against Watford at the Etihad Stadium.
Defender Micah Richards could be in contention after hamstring trouble while goalkeeper Costel Pantilimon is likely to continue and youngster Marcos Lopes could get another chance.
Midfielder Samir Nasri is the only major absentee due to a knee injury.
Man City squad: Pantilimon, Hart, Richards, Zabaleta, Kompany, Lescott, Nastasic, Demichelis, Boyata, Huws, Kolarov, Clichy, Milner, Navas, Toure, Fernandinho, Garcia, Rodwell, Lopes, Aguero, Dzeko, Jovetic.