The latest annual review of football finance by analyst Deloitte show the increase in wages outstripped the growth in revenues. It has resulted in a wages/revenue ratio of 70% in the Premier League - a record figure having crept up from the low-to-mid 60s five years ago.
Wages went up by ?201million in 2010-11 to almost ?1.6billion, a 14% rise, and overall revenues rose by 12% to ?2.27billion. This was mostly driven by a rise in income from the new TV deals, especially from overseas rights.
Alan Switzer, director in the sports business group at Deloitte, said wage control was paramount for good business.
He said: "If the wages to revenue ratio is 70% or higher it's very difficult to make an operating profit.
"In our view it is too high as a league and the clubs need to be edging back to the low 60s. Every 1% that it drops should increase operating profits by ?20m to ?25m."
The wage rises at some of the bigger clubs have been offset by significant rises in commercial income at some sides, including Manchester United, Liverpool and Manchester City.
The figures are for the 2010-11 season so are the last ones before UEFA start taking them into account for their financial fair play (FFP) calculations where clubs in European competition have to break even.
Switzer said Manchester City and Chelsea faced the greatest challenges in conforming to the FFP rules.
"Chelsea and Manchester City are the clubs which have recorded the biggest losses so they are the two which have the most to do, and to be fair to them they have been pretty public about needing to take action," he added. "A significant number of clubs around Europe have some distance to travel on the road towards compliance."