The Serbia international was on the bench for the Boxing Day clash with Liverpool after eight games out with a calf injury while fellow centre-back Martin Demichelis was absent after pulling up in training.
Top scorer Sergio Aguero (calf) and right-back Micah Richards (hamstring) remain on the sidelines while striker Stevan Jovetic is now out with a hamstring problem.
Crystal Palace top scorer Marouane Chamakh returns from suspension.
Yannick Bolasie replaced Chamakh for the 1-0 victory over Aston Villa and was arguably their most impressive player so manager Tony Pulis must decide whether to keep the winger in the team.
Match-winner Dwight Gayle is likely to have to settle for a place on the bench again, while none of Pulis' injured players are expected to be fit.
Manchester City (from): Hart, Pantilimon, Zabaleta, Kompany, Lescott, Nastasic, Boyata, Clichy, Kolarov, Nasri, Silva, Navas, Milner, Garcia, Fernandinho, Toure, Rodwell, Dzeko, Negredo, Guidetti
Crystal Palace (from): Speroni, Mariappa, Moxey, Ward, Gabbidon, Delaney, Bolasie, Jedinak, Jerome, Gayle, Puncheon, Parr, Campana, Bannan, Phillips, Williams, Price, Chamakh.