John Terry, Ramires, Eden Hazard, Oscar, and Samuel Eto'o could all sit out the last-16 tie as the Blues boss has prioritised the Champions League and Premier League over the competition, according to The Mirror.
Mourinho is believed to be keen to hand starts to Ashley Cole, John Obi Mikel, Frank Lampard, Andre Schurrle, Fernando Torres and new signing Mohamed Salah to give them match practise ahead of the Premier League run-in.
Defender Gary Cahill will miss the cup tie with a calf injury, while midfielder Nemanja Matic is doubtful after limping off during Chelsea's 1-1 draw with West Bromwich Albion.