Milner sat out the 1-0 victory against Timisoara in the Europa League play-off first leg match after arriving from Aston Villa.
Manager Roberto Mancini will monitor the fitness of striker Mario Balotelli, who picked up a knock after scoring the winner on his debut.
Summer signings Aleksander Kolarov (ankle) and Jerome Boateng (knee) are again ruled out through injury.
Source: PA
Source: PA