Despite his towering size, the Bosnian was scoring only his second headed goal of the season in Monday night's win at Wigan, a rather surprising statistic given Dzeko's tally for the campaign now stands at an impressive 14.
And with games starting to become tighter as their importance becomes more important, Mancini concedes it is an advantage City could make more of, saying: "I hope this is the start of a new Dzeko."
He added: "This guy deserves to be important. He deserves to score. That is important for the strikers. I certainly think we can exploit his size more. He can score with his head because he is strong in the air."
Meanwhile, Mancini has been urged to stop waving imaginary cards by Wolves counterpart Mick McCarthy.
Mancini has called for opponents to be sent off in three of City's last four games, twice by overtly pretending to brandish red cards.
The Italian has been criticised for his actions but complained about such behaviour himself when he alleged Manchester United striker Wayne Rooney wanted City's Vincent Kompany dismissed earlier this month.
Press Association Sport understands the Football Association will not be taking any action. However, if it continues, they may look to review the situation.
McCarthy said: "None of us should do it. It is something I don't like. There is a cultural difference. Roberto is in this country now. It is a little blip on a really good career for him at Man City because he handles himself with such good dignity and grace.
"He has done it. I wouldn't expect him to do it to one of my players or anyone else for that matter. I don't think anyone should do it. It is wrong. It looks bad and I'm sure if it is pointed out, Roberto won't do it again."