Victory over Mick McCarthy's battlers will allow City to leapfrog neighbours Manchester United and increase the pressure ahead of the Red Devils' key trip to Tottenham on Sunday.
"We should not think about it. We should only think about our games," said Mancini.
"The season is very long and we have another 17 matches to play. The table could change every three days, so we must focus only on Wolverhampton, nothing else."
Mancini's assessment is understandable. Along with Liverpool and Chelsea, City have already been one of Wolves' high-profile victims this term.
By taking points off all the established big four, plus Tottenham this term, the Blues have proved they are good enough to challenge for the biggest prizes. But, as Mancini acknowledges, that is only part of the battle.
"If you beat all these teams, the ones like Wolves, Blackpool and Aston Villa and draw against those like Chelsea and United, you win the title," he added.
"But it is not easy. The problem comes when you meet a team that, in your head, you think are easy.
"Against Arsenal, United or Chelsea, you don't need to remind yourself to concentrate. You are there a week before.
"But if you think a game is going to be easy, that is when you lose. It happens here and in Italy. There is no such thing as an easy game."