Mancini has already stated that Edin Dzeko will probably be the only new face arriving at Eastlands during the current transfer window, so most of the attention around City this month is set to be on the players who will leave.
Wayne Bridge was first man out of the exit door on Wednesday, joining West Ham for the remainder of the season.
Santa Cruz's departure was always on the cards and it seems Wright-Phillips will be leaving too.
"It is the same situation for Roque and Shaun Wright-Phillips," said Mancini. "He has two or three options."