Manager Roberto Mancini looks likely to shuffle his pack again following the Europa League victory over Salzburg, when he made eight changes from the side that drew with Stoke.
Mario Balotelli took his tally to five goals from four starts in midweek and could be paired with Carlos Tevez, who was rested.
Adam Johnson says he is beginning to feel the benefits after adopting the Mancini mantra at City.
The former Middlesbrough winger scored a superb individual goal in the victory against Salzburg which helped secure the club's passage into the knockout stages of the Europa League.
Johnson, 23, is now hoping to retain his place in the side to face Bolton and make only his sixth start in the league this season.
Mancini has been critical of the player's attitude in the past, especially after he broke into the England team.
Johnson, however, has nothing but praise for the way his boss has brought him on in the 10 months since he left the Riverside Stadium.
He said: "From the moment he came in the manager he has helped me a lot. He has told me all sorts of different things.
"He has seen a lot in his career and all his advice is starting to show a little bit in my game. It is about running off the ball, my movement and stuff like that and when to get a shot in.
"It is also about not wanting the ball at my feet all the time, and maybe trying to get in the box and on the end of a few more crosses.
"I was happy with my performance against Salzburg and really pleased with my goal. Hopefully a bit more of that will come in the next few weeks.
"I played a bit more on the left, but I am comfortable on either side and it was a slow tempo which gives you space and time to enjoy it."
Bolton manager Owen Coyle will monitor the fitness of midfielder Stuart Holden.
Holden only returned to training on Thursday after sitting out the draw with Blackpool because of a thigh strain.
The American's replacement Mark Davies could retain his place after scoring a superb equaliser last weekend.