City striker Sergio Aguero is in contention to face Newcastle after overcoming a knee injury, but defender Matija Nastasic is missing due to an ankle problem.
New signings Navas, Fernandinho, Alvaro Negredo and Stevan Jovetic could all make their debuts in what will be Manuel Pellegrini’s first competitive game in charge.
Pellegrini has backed Joe Hart to defy critics and prove he is England’s best goalkeeper.
Hart’s status as Roy Hodgson’s first choice has come under renewed scrutiny after an error in the midweek friendly against Scotland at Wembley.
Hart was at fault for Scotland’s first goal, scored by West Bromwich Albion’s James Morrison.
Pellegrini: “I think Joe Hart has to demonstrate why he is the best goalkeeper in England every week he plays.
“He’s a very important goalkeeper, I have a lot of trust in him.
“Everyone can make an error, but personally I have a lot of trust in Joe.”
Manchester City Fixtures
Monday August 19
20:00 Premier League Manchester City v Newcastle United
Sunday August 25
16:00 Premier League Cardiff City v Manchester City
Saturday August 31
12:45 Premier League Manchester City v Hull City
Saturday September 14
15:00 Premier League Stoke City v Manchester City
Sunday September 22
16:00 Premier League Manchester City v Man Utd
Saturday September 28
15:00 Premier League Aston Villa v Manchester City