Assistant manager Brian Kidd revealed Nigel de Jong is battling to overcome an ankle injury while James Milner has a hamstring problem.
However, Mario Balotelli is fit and a typically industrious performance is expected from Shaun Wright-Phillips, even though it seems increasingly likely his future lies away from Eastlands.
"There is not a problem with Shaun," said Kidd. "He has a really good mentality and is going to be a very important part of our squad from now until the end of the season.
"It is the same with Mario. With matches every three or four days, it is fantastic to have him back."