Aguero, who has a hamstring injury, joins playmaker Samir Nasri (knee) on the sidelines while midfielder Javi Garcia is also out with a knock.
Midfielder James Milner could be back in contention after a groin problem.
Manchester City (from): Hart, Pantilimon, Zabaleta, Richards, Kompany, Demichelis, Lescott, Nastasic, Boyata, Kolarov, Clichy, Silva, Navas, Milner, Toure, Fernandinho, Rodwell, Negredo, Dzeko, Jovetic.
For Chelsea, new signing Mohamed Salah could be included in the matchday squad.
The Egypt winger trained with his new team-mates on Friday for the first time since joining from Basel.
Striker Fernando Torres (knee) remains out, while midfielder Marco van Ginkel (knee) is a long-term absentee.
Chelsea (from): Cech, Ivanovic, Cole, Luiz, Ramires, Lampard, Oscar, Mikel, Schurrle, Salah, Hazard, Ba, Willian, Matic, Schwarzer, Cahill, Terry, Azpilicueta, Eto'o, Blackman, Kalas.