No games have been announced yet, but the club will be travelling to America in July and will play pre-season matches on the East Coast.
City chief executive, Garry Cook, told the club's official website: 'The summer tour of America is going to be tremendously exciting for Manchester City.
'It is going to be another groundbreaking trip for us, following on from last summer's visit to South Africa.
'I am well aware of the support there is for us in America.
"It's important for us to take City into new territories, and help spread the word to new and existing Blues fans around the world.'