Manager Roberto Mancini is debating whether to include the 20-year-old Italian, possibly on the bench.
It would be Balotelli's first outing since December 28 when he suffered a knee injury after scoring a hat-trick against Aston Villa.
Mancini said: "I will decide if he can go on the bench. If he is not fit, maybe he will need another week.
"I have not been satisfied that has been off for four weeks but he's had a problem with his knee. Hopefully he will always be able to play the last three months of the season."