Arsenal were five points clear of the chasing pack going into the lunchtime kick-off but their title hopes were dealt a major blow by the 6-3 defeat in a remarkable contest.
The Gunners, who remain top, have gone out to 7/2 to finish the season at the summit and that's the same price as Chelsea, who had to work hard for a 2-1 victory over Crystal Palace.
Liverpool and Manchester United are 9/1 and 28/1 respectively to lift the top-flight trophy.
Hull City 0 - 0 Stoke City
Cardiff 1 - 0 West Brom
Everton 4 - 1 Fulham
West Ham 0 - 0 Sunderland
Newcastle 1 - 1 Southampto
Chelsea 2 - 1 C Palace
Man City 6 - 3 Arsenal
Sky Bet also trimmed Sergio Aguero to 2/1 to be the top Premier League goalscorer with Luis Suarez their 8/13 market leader.
Everton are 3/1 for a top-four finish after a 4-1 win over Fulham saw them move fourth.
That defeat wasn't good news for the Cottagers and they are now priced at evens for relegation .
Palace (1/3) and Sunderland (4/7) are the only sides ahead of Fulham in the betting for the drop with Hull (5/2) and West Ham (3/1) also having work to do in order to secure survival.