The prolific Argentina striker has missed City's last seven games after suffering a hamstring injury while on international duty.
A comeback for the 27-year-old - who scored five goals against Newcastle on his last City appearance - would be timely with fellow forward Wilfried Bony doubtful with a hamstring problem.
Aguero told the club's website, www.mcfc.co.uk: "I do hope I can play in this game
I'm doing everything in my power to get to the match in top condition
It's been a frustrating time."
Ivory Coast international Bony was sidelined during the recent international break after being forced off early during City's goalless draw at Aston Villa on November 8.
Playmaker David Silva could also be nearing a return after a seven-game absence with a knee injury but Samir Nasri looks set to be out until February with a hamstring problem.
Saturday's encounter against Jurgen Klopp's Liverpool at the Etihad Stadium will see City come up against their former midfielder James Milner, who left the club for Anfield in the summer.
Aguero said: "He's a great player, though it will be odd to see him wearing another team's colours.
"He is a true professional and I'm sure he's going to come against us with everything he's got.
"It should be a great game
Jurgen Klopp has come in and he's a great addition to the Premier League."
Source : PA
Source: PA