Man City could seal top spot in Group A as they welcome PSG to the Etihad Stadium in the penultimate Champions League group stage clash.
Guardiola's men were defeated in the French capital when these sides met back in September, but the English champions recovered with back-to-back wins over Club Brugge to put themselves in poll position to progress as group winners.
Meanwhile, victory for Club Brugge over RB Leipzig in the other Group A fixture would set up a winner-takes-all clash for PSG in the final group game were Pochettino's side to lose in Manchester, a scenario in which they would be keen to avoid.
Here's everything you need to know about the game.
How to watch Man City vs PSG on TV/live stream
When is kick off? Wednesday 24 November, 20:00 (GMT)
Where is the match being played? Etihad Stadium
TV channel/live stream? BT Sport 2 (UK), Paramount+ (US), DAZN (Canada)
Highlights? BT Sport YouTube channel
Referee? Daniele Orsato (ITA)
VAR? Marco Di Bello (ITA)
Man City team news
Kevin De Bruyne will miss the clash for City after Guardiola confirmed the Belgian contracted COVID-19 last week.
Meanwhile, Jack Grealish is a doubt after picking up an injury on international duty with England last week, while Ferran Torres is still sidelined with a foot injury.
PSG team news
Sergio Ramos has been participating in full training for PSG recently, with Pochettino hopeful the Spaniard will be able to make the squad for the trip to Manchester.
Gianluigi Donnarumma is reportedly suffering with a bout of gastroenteritis but could return in time, while Julian Draxler is unlikely to feature after sustaining a muscle injury. Rafinha is also battling a hip injury.
Marco Verratti returned in the win over Nantes at the weekend in a boost for Pochettino, but Presnel Kimpembe is likely to miss the trip.
Man City vs PSG head-to-head record
PSG's 2-0 win over City in September didn't quite make amends for their Champions League semi-final defeat at the hands of the English champions last season, but it showed their ability to get the better of Guardiola's men.
Last season's affair in the last four of the competition was feisty, with Angel Di Maria sent off for a stamp on City midfielder Fernandinho in the second half. Verratti then also accused referee Bjorn Kuiper of swearing at several PSG players as tempers boiled over.
Man City vs PSG score prediction
PSG's performances this season as Pochettino aims to strike the correct balance among his expensively-assembled stars haven't quite been convincing.
Their victory over City at the Parc des Princes was predicated on City lacking a punch in the final third, springing forward quickly on the counter-attack and relying on the magic produced from their front three.
Neymar is certainly in better form than he was at the start of the season, but City should be able to tame PSG's threats infront of their home crowd to seal their status as group winners.
Prediction: Man City 2-1 PSG
Source : 90min